Cisplatin cervical cancer weekly

Author: kmdu

August undefined, 2024

WebNov 1, 2004 · Purpose: To evaluate patient compliance and acute toxicity accompanying concurrent weekly cisplatin and radiotherapy (RT) in the routine management of … WebDrug Dose BC Cancer Administration Guidelines CISplatin 40 mg/m2 IV in NS 500 mL with mannitol 30 g and magnesium sulfate 2 g, over 1 h Repeat weekly x 5 cycles (also see …

Randomized Phase III Trial of Cisplatin With or Without …

WebCisplatin-based concurrent chemoradiation plays an undisputed key role as definitive treatment in unresectable patients with locally advanced squamous cell carcinoma head … WebJan 18, 2024 · Typically, patients with this disease type are treated with cisplatin chemotherapy and radiation followed by internal radiation or brachytherapy. Only 30-40% of patients are alive or cancer-free at 5 years following treatment with the standard of care. eastcroft nursing home banstead surrey

Concurrent Chemoradiation With Cisplatin Every 3 Week in …

WebOct 11, 2024 · Thirty-nine patients with advanced, recurrent, or persistent cervical cancer were treated with a combination of cisplatin and topotecan as second-line chemotherapy between January 2000 and December 2015. The median patient age was 47 years (range, 32–73 years). The distribution of the histological subtypes was as follows: … WebJan 14, 2024 · CCRT consisted of weekly cisplatin 40 mg/m 2 for 5–6 weeks concurrent with radiotherapy. Pelvic external beam radiation therapy was delivered at a dose of 45 … WebJun 9, 2009 · Weekly cisplatin, hydroxyurea + cisplatin, 5-FU + cisplatin are tested in clinical trials. Weekly cisplatin needs frequent hospital visits and had a poor compliance profile in korea. Combination chemotherapy regimens had more adverse effects than weekly cisplatin without improving outcomes. eastcroft nursing home sm7 3ex

Weekly cisplatin 20 mg/m2 in patients with carcinoma of …

Comparison of platinum monotherapy with concurrent …

http://www.bccancer.bc.ca/chemotherapy-protocols-site/Documents/Gynecology/GOCXCRT_Protocol.pdf WebAs a second-generation platinum derivative, nedaplatin has been demonstrated to be equivalent to or have superior antineoplasic activity to cisplatin with less toxicity in cervical cancer. 24–26 The majority of our patient population was administered with weekly nedaplatin. Grade 3 acute toxicities were observed in only 4 patients (14.3% ... eastcroft nursing home bansteadWebSep 18, 2024 · In a double-blind, phase 3 trial, we randomly assigned patients with persistent, recurrent, or metastatic cervical cancer in a 1:1 ratio to receive pembrolizumab (200 mg) or placebo every 3... eastcroft road grangetown

"WebFeb 21, 2024 · Efficacy. In the frame of conventionally fractionated radiotherapy, no statistically significant difference in overall survival was observed between low-dose weekly and high-dose three-weekly … " - Cisplatin cervical cancer weekly

Cisplatin cervical cancer weekly

Current Management of Locally Advanced and …

WebCisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other cancers. It is best to read … WebJan 14, 2024 · Patients with IIB-IVA cervical cancer were randomly allocated in a 1:1 ratio to NACT with weekly cisplatin and paclitaxel followed by CCRT or to CCRT alone. The randomization scheme prepared by the study statistician using a random number table, with the results entered by a study manager not involved with patient recruitment.

Did you know?

WebSep 21, 2016 · Single-agent cisplatin (CPT) has been the standard systemic chemotherapeutic agent for the treatment of advanced/recurrent and metastatic squamous cell carcinoma of the uterine cervix since the Gynecologic Oncology Group (GOG) phase II trial of cisplatin 50 mg/m 2 demonstrated a 44% objective response rate in 25 previously … WebIntroduction. Concurrent chemo-radiation (chemoRT) became the standard of care for patients with advanced cervical cancer following the NIH Clinical Alert announcement in …

WebJan 10, 2024 · Background Currently, the standard treatment for locally advanced cervical cancer is concurrent chemoradiation (CCRT). The effect of neoadjuvant chemotherapy in advanced cervical cancer is controversial. Studies have shown that the addition of a weekly regimen of neoadjuvant chemotherapy (NACT) followed by CCRT may be … http://www.nrgoncology.org/Home/News/Post/adding-atezolizumab-to-cisplatin-and-radiotherapy-for-node-positive-locally-advanced-cervical-cancer-nrg-gy017

WebApr 19, 2024 · Cisplatin and carboplatin are two platinum drugs commonly used in chemotherapy. It is investigated that the main role of chemotherapy in CCRT is to enhance the sensitivity of radiotherapy (RT), and carboplatin concomitant with RT has similar efficacy and safety with single cisplatin [ 25, 26 ]. Similarly, another study confirmed this … WebA multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors

WebNov 11, 2024 · Kim YS, Shin SS, Nam JH, et al. Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic …

WebJul 19, 2016 · Carboplatin yielded comparable results to cisplatin in concurrent chemo-radiation for locally advanced cervical cancer. In addition, carboplatin was associated with a better compliance rate and was associated with less of anemia, neutropenia and nephrotoxicity. ... CCRT with weekly cisplatin at a dose of 40 mg/m 2 or weekly … cubic meter to gpm converterWebNov 1, 2004 · Methods and materials. Locally advanced or high-risk early-stage cervical cancer patients treated with RT and concurrent weekly cisplatin at a dose of 40 mg/m 2 i.v. (maximum dose, 70 mg) for five cycles. Definitive RT included whole pelvis external beam RT to the International Commission on Radiation Units and Measurements reference … cubic meter to inchesWebAug 26, 2024 · NAC consisted of intravenous cisplatin 50 mg/m 2 on day 1 and gemcitabine 1,000 mg/m 2 on day 1 and day 8 every 3 weeks for three cycles. NAC was followed by standard CRT, which started 3 to 4 weeks … eastcroft park schoolWebApr 7, 2024 · Purpose To analyze the effect of cisplatin cycles on the clinical outcomes of patients with locally advanced cervical cancer (LACC) treated with concurrent … eastcroft park primary schoolWebMethods: This retrospective analysis included women with locally advanced cervical cancer treated with NACT-CCRT between September 2011 and September 2014. Neoadjuvant chemotherapy included paclitaxel plus cisplatin (TP group; 62 patients) or paclitaxel plus loplatin (TL group; 58 patients), which were administered three weekly, and cisplatin ... cubic meter to gpmWebMay 8, 2006 · Evidence from the GOG125 study indicates that weekly cisplatin at 40 mg/m 2 for six weeks is equally effective yet less toxic than cisplatin and 5-fluorouracil in a classic 21-day schedule [ 13 ]; nonetheless, the choice of 40 mg/m 2 as the dose for weekly cisplatin for phase III chemoradiation trials was not based on previous phase I data, and … eastcroft roses kentWebApr 10, 2024 · and the Thai Cooperative Group, compared weekly cisplatin cancer therapy to every-3-week chemotherapy for locally advanced cervical cancer. In addition, the concurrent chemoradiotherapy plus brachytherapy with carboplatin and paclitaxel in patients with locally advanced cervical cancer (OUTBACK) trial [NCT01414608]8 was eastcroft park school kirkby